The United States earned its third-consecutive Solheim Cup by collecting eight of 12 points in Sunday's singles competition at Rich Harvest Farms.
The Americans also registered their eighth-win overall by posting a 16-12 total victory.
"Most of the day I was thinking this wasn't going to happen," said American captain Beth Daniel. "I can't even believe they've done this."
The US win also means the European drought on US soil continues. When Christina Kim went 1-up against Europe's Tania Elosegui with one to play, that guaranteed a half point for the United States.
Morgan Pressel won the par-three 16th to ice a 3 and 2 win over Anna Nordqvist that got the Americans to 14 1/2 points, enough for a third consecutive win.
Michelle Wie's 3-0-1 record was the best of all the US golfers this week.
"People have seen a different side of me," Wie said. "This was just a lot of fun. There's nothing to describe it."
The Americans were up 13-10 and in need of one point to at least retain the Cup. In the four matches underway, the Americans were behind in one, but held close 1-up leads in the other three.
On No. 16 Kim rolled in an eight-foot birdie putt to give her a 2-up lead over Elosegui. Despite losing 17, Kim was still guaranteed a half point.
Pressel was 2-up with three holes to play when she failed to make the green at 16. Nordqvist missed a 10 foot put for par, allowing the Americans to retain the Solheim Cup.
"It's very emotional," said Pressel. "It's been a long week and we played great. I'm so proud of our team.
"I wasn't sure if I was going to make the team for a while this year, so for Beth to put me out late like I asked and me to come through, it's great."
The Europeans, who have never won on the Americans' home turf, came into the event as huge underdogs.
"The Americans came out firing on all cylinders," said Alison Nicholas, the European captain. "We've had a great week. I had a fun week. The girls battled hard."