Following their win over Burkina Faso earlier this month, South Africa have moved up two places to position 47 in the latest FIFA/Coca Cola World rankings.
Bafana Bafana have also climbed two places to number seven in the Confederation of African Football (CAF) rankings.
Meanwhile, the Netherlands ended Spain's reign of more than a year at the summit to claim the top spot for the first time ever.
'The Oranje' thus profited from Spain's defeat by Italy - in a friendly that cost the world and European champions valuable points - to become only the seventh team (after Argentina, Brazil, France, Germany, Italy and Spain) to sit atop the global ladder.
There has also been a dramatic change in South America, with fifth-placed Uruguay becoming the top-ranked South American team following Brazil's (6th, down 2) loss to Germany (3rd, unchanged).
England also reaped the rewards of Brazil's defeat to move up two places to fourth.
Also inside the top 50, Russia (13th, up 5), Nigeria (38th, up 5) and Algeria (46th, up 6) are the biggest gainers.