Wasps lock Joe Launchbury is set to make his first Test start after England coach Stuart Lancaster made six changes to the side for Saturday's international against South Africa at Twickenham.
The 21-year-old Launchbury replaced club-mate Tom Palmer in a starting side announced by Lancaster on Thursday that was much altered from the one beaten 20-14 by Australia at Twickenham last weekend.
No 8 Ben Morgan, blindside flanker Tom Wood and loosehead prop Alex Corbisiero all make their first starts of the European autumn series, with Wood in the XV for the first time since last year's World Cup following a toe injury.
In the backs, Mike Brown, the Harlequins full-back, starts on the left wing with England using two full-backs - Alex Goode is at No 15 - in a bid to counter the Springboks' expected aerial threat.
Meanwhile Ben Youngs is preferred to Danny Care at scrum-half.
England will be looking for their first win over a major southern hemisphere nation under Lancaster having lost twice and drawn once in a three-Test series away to South Africa in June before last week's Wallaby reverse.
Springboks coach Heyneke Meyer named Wednesday a starting XV unchanged from the one that beat Scotland 21-10 at Murrayfield last weekend.
Lancaster's men conclude their European autumn campaign against world champions New Zealand at Twickenham on December 1.
Alex Goode; Chris Ashton, Manu Tuilagi, Brad Barritt, Mike Brown; Toby Flood, Ben Youngs; Ben Morgan, Chris Robshaw (capt), Tom Wood; Geoff Parling, Joe Launchbury; Dan Cole, Tom Youngs, Alex Corbisiero
Replacements: David Paice, David Wilson, Mako Vunipola, Mouritz Botha, James Haskell, Danny Care, Owen Farrell, Jonathan Joseph