Rory McIlroy, chasing a return to the world No. 1 ranking in his first start in seven weeks, fired a second-round 65 on Friday to grab the lead in the WGC-Mexico Championship.
The Northern Irishman vaulted into a two-shot lead ahead of five-time major winner Phil Mickelson, American Justin Thomas and England's Ross Fisher.
Four-time major champion McIlroy reached a total of nine-under 133 at the Chapultepec Golf Club for his first 36 hole lead on the USPGA Tour since the 2014 PGA Championship at Valhalla.
Mickelson carded three-under 68 for a seven-under total of 135. Fisher also posted a 68 and Thomas signed for a 66.
For a victory to propel McIlroy back to number one in the world, current number one Dustin Johnson would have to finish in a tie for fourth or worse.
Johnson was also in the hunt after a five-under 66 that put him in a three-way tie for fifth on 136 with England's Andy Sullivan (65) and Daniel Berger (66).
McIlroy finished with six birdies, two bogeys and an eagle on the par-four 14th. His lead could have been larger but he missed a four-foot putt on 17 and a three foot putt for birdie and settled for a par on 18.
"Look, I'm in a great position. But I felt like I could have been a few more ahead," McIlroy said.
McIlroy already has two WGC victories on his resume, the 2014 Bridgestone and the 2015 WGC-Cadillac Match Play in San Francisco. He is trying to join Tiger Woods (18), Johnson (three) and Geoff Ogilvy (three) as the only players with three or more wins in World Golf Championships events.
Johnson played in the marquee trio Friday with McIlroy and Japan's Hideki Matsuyama who shot his second straight 72.
Johnson, who moved to number one with his victory at Riviera Country Club two weeks ago, capped his round with his seventh birdie of the day at 18. He had a bogey at 14 but then made birdie on three of his final four holes to keep McIlroy in his sights.