The Chiefs and Stormers go head-to-head in a Super Rugby clash that will shake up the battle for top spot.
The Chiefs go into Saturday's game two points behind the Crusaders, who have a bye, meaning they are able to seize control of the New Zealand conference.
The Stormers 13 points clear at the top of the Africa One conference, but just two points behind the Chiefs.
A win could see the Cape Town-based franchise claim first place in the combined standings, the same spot being chased by the Chiefs.
The Brumbies have lost three games, but still lead the Australian conference. They are at home in Canberra to the troubled Reds.
The Reds, already without suspended playmaker Quade Cooper, have dropped Wallabies scrumhalf Nick Frisby as they look to stem a run of five consecutive defeats and deal with off-field disciplinary issues.
The Jaguares are in Durban to play the Sharks - with both sides on 18 points, five behind the Lions in the Africa Two conference.
The Argentinian franchise has a game in hand.
Australia's Western Force and South African franchise Southern Kings, two sides likely to be in the firing line should the competition be trimmed from 18 to 15 teams, meet in Perth on Sunday.
Saturday, April 8:
Stormers v Chiefs
(Newlands, Cape Town - Kick-off: 17.15; 15.15 GMT; 03.15, Sunday, April 9 NZ time)
The Stormers have denied that 'revenge' was a word bandied about in camp this week.
However, coach Robbie Fleck felt the encounter represents a chance for his team to measure how much progress they have made since the 21-60 loss to the Chiefs in the quarterfinal last year.
"We can see improvements from last year, but this is the real test," Fleck told the media at the team's Cape Town base this week.
"This is the team that put us to the sword last year. So there is a big motivation for this game," he added.
"We haven't faced a team as good as them this year and this is a great chance for us to see how far we have come."
The Chiefs headed to Cape Town without flank Sam Cane and prop Nepo Laulala due to concussion, while centre Johnny Fa'auli has been suspended for a dangerous tackle.
Chiefs coach Dave Rennie said they will back their high-paced game to get them over this hurdle.
"We have clarity of how we are going to play," Rennie said, adding: "It's going to be a big step up from our performances over the last couple of weeks.
"We offload the most in the competition and it's your ability to get in behind defenders to keep the ball alive."
He denied that former Blues assistant coach Paul Feeney will be able to share any trade secrets with the Stormers, as the Kiwi has never been part of the Chiefs environment.
"He won't know how we go about things, but there is no doubt the Stormers would have had a good look at us through analysis.
"They have an outstanding pack, the scrum has been dominant, have a strong line-out. We need to be really strong in those areas."
2016: Chiefs won 60-21, Cape Town (quarterfinal)
2015: Chiefs won 28-19, Cape Town
2014: Chiefs won 36-20, Hamilton
2013: Stormers won 36-34, Cape Town
2011: Chiefs won 30-23, Hamilton
Prediction: The Chiefs have won each of their last three games against the Stormers, including a 60-21 thumping in the 2016 play-off; the biggest win in the history of the fixture. The Stormers have won their last five in a row, the last time they went on a longer run was a six-game winning streak at the beginning of the 2012 season. The Chiefs have won seven of their last eight games outside of New Zealand, including each of their last three by an average margin of 32 points. The Stormers gain an average of 641m per game this season, the most of any team in the competition and nearly 200m more per game than the Chiefs (445 metres). James Lowe has scored once in each of his last three games against the Stormers, as well as providing a brace of try assists in his last fixture against them. The Stormers have made progress, but we don't believe enough. The Chiefs should win by at least 10 points.
Stormers: 15 Sarel Marais, 14 Cheslin Kolbe, 13 EW Viljoen, 12 Dan du Plessis, 11 Dillyn Leyds, 10 Robert du Preez, 9 Dewaldt Duvenage, 8 Sikhumbuzo Notshe, 7 Siya Kolisi (captain), 6 Cobus Wiese, 5 Pieter-Steph du Toit, 4 Eben Etzebeth, 3 Wilco Louw, 2 Bongi Mbonambi, 1 Jacobus Janse van Rensburg.
Replacements: 16 Ramone Samuels, 17 Oliver Kebble, 18 Frans Malherbe, 19 Jan de Klerk, 20 Nizaam Carr, 21 Justin Phillips, 22 Kurt Coleman, 23 Dan Kriel.
Chiefs: 15 Damian McKenzie, 14 Toni Pulu, 13 Anton Lienert-Brown, 12 Stephen Donald, 11 James Lowe, 10 Aaron Cruden (captain), 9 Tawera Kerr-Barlow, 8 Michael Leitch, 7 Lachlan Boshier, 6 Liam Messam, 5 Brodie Retallick, 4 Dominic Bird, 3 Atu Moli, 2 Hika Elliot, 1 Kane Hames.
Replacements: 16 Brayden Mitchell, 17 Siegfried Fisi'ihoi, 18 Sosefo Kautai, 19 Taleni Seu, 20 Mitchell Brown, 21 Finlay Christie, 22 Sam McNicol, 23 Shaun Stevenson.
Referee: Jaco Peyper (South Africa)
Assistant referees: Jaco van Heerden (South Africa), Cwengile Jadezweni (South Africa)
TMO: Shaun Veldsman (South Africa)
For more rugby news, visit Rugby365.com