Ireland will play South Africa, Fiji and Argentina in Dublin in November, the Irish Rugby Football Union (IRFU) announced on Thursday.
Joe Schmidt's side face the Springboks at the Aviva Stadium on November 12. They will play Fiji six days later before closing the year against Argentina on November 25.
South Africa's last visit to Dublin was in November 2014, when the hosts prevailed 29-15.
"This November's Guinness Series promises to have some added edge, with recent fixtures against South Africa and Argentina fresh in the memory," said Padraig Power, the IRFU's commercial and marketing director.
"Argentina ended Ireland's Rugby World Cup hopes in October 2015, while the Springbok edged a thrilling Test series last June after Ireland had made history in Newlands.
"Fiji's exciting brand of free-flowing rugby will be showcased for the very first time at the Aviva Stadium as the South Sea Islanders play in Dublin for the first time since 2009."