(Kings Park, Durban - Kick-off: 17.15; 15.15 GMT)
The Stormers are looking forward to the brutality of a South African derby after having faced four New Zealand teams in a row.
"It is always tough going to Kings Park and we know that we will be seriously tested over there, but our focus is on developing our own game," Stormers coach Robbie Fleck said.
"The team would like to build on our win against the Blues, so our focus this week has been on backing up on that performance," he said.
Sharks coach Robert du Preez stated the obvious when he said it is "an important match".
But he left no doubt what their mental approach will be.
"We are treating it as a Test Match," Du Preez said.
"It's time for our individuals to make the step-up and nothing but their best will be good enough.
"We are playing in front of our home crowd and we need to reward our loyal fans with a performance that all of us can be proud of."
The Stormers are ready for what is likely to be the most brutally physical derby of the weekend.
"We have put some good plans in place and we are looking forward to seeing how we go against them," Fleck said.
"I think last year they defended pretty well against us at Newlands and we had our opportunities, but we didn't execute it that well.
"We let them in with a soft try at the end.
"They were deserved winners last year. We are going to have to really be up for this one, it is a tough game and I've certainly felt that apart from their physicality they are looking pretty well conditioned, so they can go for the 80 minutes, which means it is going to be a good battle."
2016: Sharks won 18-13, Cape Town
2015: Sharks won 34-12, Durban
2015: Stormers won 29-13, Cape Town
2014: Sharks won 34-10, Cape Town
2014: Stormers won 21-19, Durban
Prediction: The Sharks have won six of their last nine games against the Stormers, though three of the last five iterations of this fixture have been won by the away team on the day. The Sharks are undefeated in their last nine games on home turf, having conceded an average of just 13 points per game across that period. he Stormers have won five of their last six South African derbies, though they dropped a five-game winning streak with a 29-16 loss to the Lions in their last such fixture. The Sharks have conceded only nine tries across the opening 20 minutes of each half combined so far this season, the second fewest of any team in the competition (Hurricanes, Seven). SP Marais has made a competition-high 25 offloads this season, contributing two or more offloads in six of his last eight appearances. It will be close and intriguing, even entertaining. We feel the Stormers have just too much class and should win by a converted try.
Sharks: 15 Lwazi Mvovo, 14 Jacobus van Wyk, 13 Lukhanyo Am, 12 Johan Deysel, 11 Sibusiso Nkosi, 10 Garth April, 9 Jacobus Reinach, 8 Daniel du Preez, 7 Jean-Luc du Preez, 6 Philip van der Walt (captain), 5 Stephan Lewies, 4 Ruan Botha, 3 Coenraad Oosthuizen, 2 Mahlatse Ralepelle, 1 Thomas du Toit.
Replacements: 16 Franco Marais, 17 Tendai Mtawarira, 18 Lourens Adriaanse, 19 Etienne Oosthuizen, 20 Lubabalo Mtembu, 21 Michael Claassens, 22 Benhard Janse van Rensburg, 23 Odwa Ndungane.
Stormers: 15 Sarel Marais, 14 Cheslin Kolbe, 13 EW Viljoen, 12 Damian de Allende, 11 Dillyn Leyds, 10 Kurt Coleman, 9 Jano Vermaak, 8 Nizaam Carr, 7 Siya Kolisi (captain), 6 Kobus van Dyk, 5 Pieter-Steph du Toit, 4 Eben Etzebeth, 3 Frans Malherbe, 2 Bongi Mbonambi, 1 Oliver Kebble.
Replacements: 16 Ramone Samuels, 17 Alister Vermaak, 18 Wilco Louw, 19 Chris van Zyl, 20 Sikhumbuzo Notshe, 21 Dewaldt Duvenage, 22 Juan de Jongh, 23 Seabelo Senatla.
Referee: Marius van der Westhuizen (South Africa)
Assistant referees: AJ Jacobs (South Africa), Archie Sehlako (South Africa)
TMO: Marius Jonker (South Africa)
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