FA Cup holders Arsenal were sensationally dumped out of the competition by Nottingham Forest on Sunday, joining Leeds United as big-name casualties on a day of shocks.
Elsewhere, West Ham stayed alive with a goalless draw at Shrewsbury and Tottenham scored three goals in just eight second-half minutes to see off the challenge of League One side AFC Wimbledon.
Championship side Forest revived memories of their glory years under Brian Clough, putting 13-times winners Arsenal to the sword in an incident-packed win at the City Ground.
Eric Lichaj opened the scoring for the home side but Per Mertesacker equalised just three minutes later.
However, Forest continued to probe an inexperienced Arsenal line-up and got their reward just before half-time when Lichaj volleyed in spectacularly from the edge of the box.
Arsenal manager Arsene Wenger, serving a touchline ban, was forced to watch powerless from the stands as Rob Holding conceded a penalty that Ben Brereton converted to stretch home side's lead to 3-1.
Danny Welbeck gave Arsenal hope with just over 10 minutes to go but Kieran Dowell netted from the penalty spot again to seal a 4-2 win for the second-tier side over the Premier League visitors.
In the early kick-off, on-loan forward Shawn McCoulsky headed in a dramatic 89th-minute winner for Welsh club Newport to seal a 2-1 victory against 1972 Cup winners Leeds.
Leeds had taken an early lead at Rodney Parade when Gaetano Berardi's deflected long-range shot found the net.
But Newport, currently 11th in League Two -- the fourth tier of the English game -- levelled 14 minutes from time when Leeds defender Conor Shaughnessy sliced into his own net.
Infused with fresh belief in front of a passionate Welsh crowd, Newport pressed for a winner, and with a minute to go on-loan substitute McCoulsky rose highest at a corner to head in the decisive goal and send the stadium into raptures.
Much-changed Leeds were then reduced to 10 men when substitute Samuel Saiz was immediately sent off over an off-the-ball incident.
"This is much better beating Championship teams like Leeds," said Newport manager Michael Flynn. "I don't want to be winning relegation battles, I want to be winning FA Cup ties and climbing the table."
It is another miserable result in the FA Cup for Leeds, who crashed out in the fourth round last year to non-league Sutton United.
- Hart saves -
West Ham had goalkeeper Joe Hart to thank for keeping them in the Cup with a 0-0 draw after an uninspired performance against Shrewsbury Town of the third tier.
The England goalkeeper, returning to the club where he started his career, was handed a cap from the crowd as he battled against the slanting winter sun.
He made a fine save from Mat Sadler with about 10 minutes to go until the interval and repeated the trick against Alex Rodman to keep the score at 0-0.
The League One high-fliers continued to take the game to David Moyes's team in the second half but there were few clear-cut opportunities for either side.
Shrewsbury's Jon Nolan had a golden chance to seal a dramatic victory in the dying minutes of normal time but blazed over and the two sides will meet again at the London Stadium.
"The players are a little bit deflated almost," said Shrewsbury Town manager Paul Hurst.
"But we have a replay to look forward to," he added. "We know it will be tough. They will be at home, more comfortable in their own stadium."
At Wembley, Harry Kane broke the deadlock against AFC Wimbledon with just under half an hour to go before Kane again and Jan Vertonghen made it 3-0 to put the game beyond the reach of the visitors.
On Saturday, League Two Coventry City sent Premier League side Stoke City crashing out, prompting the sacking of Mark Hughes.