David Nalbandian was ruled out of the US Open on Tuesday after suffering a rib injury, the organisers confirmed.
Nalbandian, the former world number three and Wimbledon runner-up in 2002, had been due to face Argentine compatriot, and 2009 champion in New York, Juan Martin del Potro in the first round on Wednesday.
His place in the draw is expected to be taken by French lucky loser Florent Serra.
"I suffered the injury in training. I am sorry that I could not attend the US Open," Nalbandian later tweeted.
"But I hope to be fit for the Davis Cup semi-final against the Czech Republic in September."